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Article

Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody.

Infection and immunity - 1 Sept 1990

Blanco L, Choi E M, Connolly K, Thompson M R, Bonventre P F

Abstract excerpt

Toxic shock syndrome toxin 1 (TSST-1), a 22-kilodalton protein made by strains of Staphylococcus aureus harboring the chromosomal toxin gene, may elicit toxic shock syndrome in humans. In vitro, TSST-1 induces T cells to proliferate and macrophages to secrete interleukin-1. To conduct a structure-function analysis, point mutations on the TSST-1 gene were generated by site-directed mutagenesis to identify amino...

Topics

Animals
Antibodies, Monoclonal
Bacterial Toxins
Base Sequence
Binding, Competitive
Blotting, Western
Cloning, Molecular
Electrophoresis, Polyacrylamide Gel
Enterotoxins
Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epitopes

Escherichia coli

Mice

Mitogens

Molecular Sequence Data

Mutation

Neutralization Tests

Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 1696937
DOI: 10.1128/iai.58.9.3020-3028.1990
PMCID: PMC313605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1696937-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody.PMID 1696937Read ↗

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