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Article

H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.

Cancer letters - 30 Jun 2003

Satomi Yoshiko, Bu Ping, Okuda Masato, Tokuda Harukuni, Nishino Hoyoku

Abstract excerpt

The tumor-initiating activity of nitric oxide (NO) in carcinogenesis was assessed using (+/-)-(E)-4-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR1), a synthetic NO donor. Topical application of NOR1 followed by 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment twice a week for 20 weeks resulted in the development of papillomas in mice. All of the papillomas examined contained H-ras mutations...

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Identifiers

PMID: 12860284
DOI: 10.1016/s0304-3835(03)00188-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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