Article
Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium.
Environmental and molecular mutagenesis - 1 Jan 2000
Zhuang J C, Wright T L, deRojas-Walker T, Tannenbaum S R, Wogan G N
Abstract excerpt
Characterization of mutations induced by NO in different experimental systems will facilitate elucidation of mechanisms underlying its genotoxicity. The mutagenic specificity of NO in human cells is of particular interest in view of its potential role in inflammation-associated carcinogenesis. We compared mutagenesis in human lymphoblastoid TK6 cells and in Salmonella typhimurium induced by exposure to NO...
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