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Article

Role of nitric oxide in tumour progression with special reference to a murine breast cancer model

1 Feb 2002

Abstract excerpt

Nitric oxide (NO) is a potent bioactive molecule produced in the presence of NO synthase (NOS) enzymes, which mediates numerous physiological functions under constitutive conditions. Sustained overproduction of NO (and NO-reaction products), typically under inductive conditions, can lead to cell cycle arrest and cellular apoptosis. Furthermore, carcinogenesis may result from mutational events following...

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PMID: 11934255
DOI: 10.1139/y02-007

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