Article
Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells.
Biomolecules - 7 Feb 2023
Cheng Robert Y S, Burkett Sandra, Ambs Stefan, Moody Terry, Wink David A, Ridnour Lisa A
Abstract excerpt
The small endogenous signaling molecule nitric oxide (NO) has been linked with chronic inflammation and cancer. The effects of NO are both concentration and temporally dependent; under some conditions, NO protects against damage caused by reactive oxygen species and activates P53 signaling. During chronic inflammation, NO causes DNA damage and inhibits repair proteins. To extend our understanding of the roles of...
Topics
- Humans
- Female
- Nitric Oxide
- Tumor Suppressor Protein p53
- Epithelial Cells
- Mutation
- Inflammation
- Breast Neoplasms