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Article

Macrophage-independent fungicidal action of the pulmonary collectins.

The Journal of biological chemistry - 19 Sept 2003

McCormack Francis X, Gibbons Reta, Ward Susan R, Kuzmenko Alexander, Wu Huixing, Deepe George S

Abstract excerpt

Histoplasma capsulatum (Hc) is a facultative intracellular fungal pathogen that causes acute and chronic pneumonia. In this study, we investigated the role of the pulmonary collectins, surfactant proteins (SP) A and D, in the clearance of Hc yeast from the lung. Exposure of yeast to either collectin induced a dose-dependent decrease in [3H]leucine incorporation by several strains of Hc. This decrement was...

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Identifiers

PMID: 12857753
DOI: 10.1074/jbc.M303086200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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