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Article

Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.

The Journal of clinical investigation - 1 May 2003

Wu Huixing, Kuzmenko Alexander, Wan Sijue, Schaffer Lyndsay, Weiss Alison, Fisher James H, Kim Kwang Sik, McCormack Francis X

Abstract excerpt

The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this study, we examined the effect of SP-A and SP-D on the growth and viability of Gram-negative bacteria. The pulmonary clearance of Escherichia coli K12 was reduced in SP-A-null mice and was increased in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12750409
DOI: 10.1172/JCI16889
PMCID: PMC155045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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