Article
Role of collectins in innate immunity against aspergillosis.
Medical mycology - 1 May 2005
Madan T, Kaur S, Saxena S, Singh M, Kishore U, Thiel S, Reid K B M, Sarma P U
Abstract excerpt
The protective role of lung surfactant proteins SP-A, SP-D and MBL in the host defense against both allergic and invasive aspergillosis was identified and established by a series of in vitro and in vivo studies. Therapeutic administration of SP-D and MBL proteins in a murine model of pulmonary invasive aspergillosis rescued mice from death. In mice mimicking human allergic bronchopulmonary aspergillosis, SP-A and...
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