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Article

<i>Histoplasma capsulatum</i> α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor

16 Jan 2007

Abstract excerpt

Successful infection by fungal pathogens depends on subversion of host immune mechanisms that detect conserved cell wall components such as beta-glucans. A less common polysaccharide, alpha-(1,3)-glucan, is a cell wall constituent of most fungal respiratory pathogens and has been correlated with pathogenicity or linked directly to virulence. However, the precise mechanism by which alpha-(1,3)-glucan promotes...

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PMID: 17227865
DOI: 10.1073/pnas.0609848104

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