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Article

Intracellular parasitism by Histoplasma capsulatum: fungal virulence and calcium dependence.

Science (New York, N.Y.) - 17 Nov 2000

Sebghati T S, Engle J T, Goldman W E

Abstract excerpt

Histoplasma capsulatum is an effective intracellular parasite of macrophages and causes the most prevalent fungal respiratory disease in the United States. A "dimorphic" fungus, H. capsulatum exists as a saprophytic mold in soil and converts to the parasitic yeast form after inhalation. Only the yeasts secrete a calcium-binding protein (CBP) and can grow in calcium-limiting conditions. To probe the relation...

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Identifiers

PMID: 11082066
DOI: 10.1126/science.290.5495.1368

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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