Article

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

2022-01-01

Abstract excerpt

The fungal pathogen Histoplasma capsulatum ( Hc ) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection, greatly expanding our understanding of host gene networks targeted by Hc . We identified pathways that have not...

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Literature Corpus work: 784849e8-74fc-541e-8234-0131f7440a27
DOI: 10.1101/2021.12.30.474615

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