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Article

Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells

16 May 2024

Abstract excerpt

Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health. The small size of Af spores suggests that interactions with alveolar epithelial cells (AECs) are frequent; thus, we hypothesized that spore uptake by AECs is important for driving fungal killing and susceptibility to Aspergillus -related disease. Using...

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PMID: 38846001
DOI: 10.1016/j.isci.2024.109939

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