Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages

29 Sept 2022

Abstract excerpt

The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages. To interrogate the molecular mechanisms underlying this interaction, we conducted a host-directed CRISPR-Cas9 screen and identified 361 genes that modify macrophage susceptibility to Hc infection, greatly expanding our understanding of host gene networks targeted by Hc. We identified pathways that have not been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Studies on Chitinases and Chitosanases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36174103
DOI: 10.1371/journal.ppat.1010237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophagesPMID 36174103Read ↗

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophagesSemantic proximity Read ↗

The Interaction of Human Pathogenic Fungi With C-Type Lectin ReceptorsSemantic proximity Read ↗

Fungal hyphae instigate non-canonical inflammatory cell death in macrophagesSemantic proximity Read ↗

Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophagesSemantic proximity Read ↗

Pattern recognition receptors in antifungal immunitySemantic proximity Read ↗

Functional Analysis of Host Factors that Mediate the Intracellular Lifestyle of Cryptococcus neoformansSemantic proximity Read ↗

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinerySemantic proximity Read ↗

Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathwaySemantic proximity Read ↗

<i>Histoplasma capsulatum</i> α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptorSemantic proximity Read ↗

Mucor circinelloides Thrives inside the Phagosome through an Atf-Mediated Germination PathwaySemantic proximity Read ↗

Global analysis of fungal morphology exposes mechanisms of host cell escapeSemantic proximity Read ↗

Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host PhagocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.