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Article

Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes.

Biochimica et biophysica acta - 9 Jul 2003

Zhu Jianfeng, Spencer Eliott D, Kaspar Roger L

Abstract excerpt

TOP mRNAs (contain a 5' terminal oligopyrimidine tract) are differentially translated in rapamycin-treated human B lymphocytes. Following rapamycin treatment, ribosomal protein (rp) and translation elongation factor TOP mRNAs were translationally repressed, whereas hnRNP A1 TOP mRNA was not. Poly(A)-binding protein (Pabp1) TOP mRNA was translationally repressed under all conditions tested. To investigate the...

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Identifiers

PMID: 12850272
DOI: 10.1016/s0167-4781(03)00117-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes.PMID 12850272Read ↗

Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and ProteomicsSemantic proximity Read ↗

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kSemantic proximity Read ↗

The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.Semantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

A critical role for non-coding RNA <i>GAS5</i> in growth arrest and rapamycin inhibition in human T-lymphocytesSemantic proximity Read ↗

Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity Read ↗

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.Semantic proximity Read ↗

TOP mRNAs are translationally inhibited by a titratable repressor in both wheat germ extract and reticulocyte lysate.Semantic proximity Read ↗

La protein has a positive effect on the translation of TOP mRNAs in vivoSemantic proximity Read ↗

The rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5' long terminal repeat.Semantic proximity Read ↗

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent mannerSemantic proximity Read ↗

Ribosomal selection of mRNAs with degenerate initiation triplets.Semantic proximity Read ↗

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