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Article

The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.

Nucleic acids research - 1 Mar 1997

Avni D, Biberman Y, Meyuhas O

Abstract excerpt

TOP mRNAs are vertebrate transcripts which contain a 5'terminal oligopyrimidine tract (5'TOP), encode for ribosomal proteins and elongation factors 1alpha and 2, and are candidates for growth-dependent translational control mediated through their 5'TOP. In the present study we show that elongation factor 2 (EF2) mRNA is translationally regulated in a growth-dependent manner in cells of hematopoietic origin, but...

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Identifiers

PMID: 9023110
DOI: 10.1093/nar/25.5.995
PMCID: PMC146534

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Related research

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The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.PMID 9023110Read ↗

TOP mRNAs are translationally inhibited by a titratable repressor in both wheat germ extract and reticulocyte lysate.Semantic proximity Read ↗

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomesSemantic proximity Read ↗

Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes.Semantic proximity Read ↗

mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decaySemantic proximity Read ↗

The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level.Semantic proximity Read ↗

Rare codon translation regulates growth factor-dependent cell proliferationSemantic proximity Read ↗

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.Semantic proximity Read ↗

ARF suppresses 5’-terminal oligopyrimidine mRNA translationSemantic proximity Read ↗

Diversity in translational regulation.Semantic proximity Read ↗

Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylation.Semantic proximity Read ↗

La protein has a positive effect on the translation of TOP mRNAs in vivoSemantic proximity Read ↗

Effect of 3'UTR length on the translational regulation of 5'-terminal oligopyrimidine mRNAs.Semantic proximity Read ↗

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