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Article

TOP mRNAs are translationally inhibited by a titratable repressor in both wheat germ extract and reticulocyte lysate.

FEBS letters - 13 Aug 1999

Biberman Y, Meyuhas O

Abstract excerpt

Vertebrate TOP mRNAs contain a 5' terminal oligopyrimidine tract (5' TOP), which is subject to selective translational repression in non-growing cells or in cell-free translation systems. In the present study, we monitored in vitro the effect of increasing amounts of a 16 nucleotides long oligoribonucleotide representing the 5' terminus of mouse ribosomal protein S16 mRNA on the translation of TOP and non-TOP...

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Identifiers

PMID: 10462043
DOI: 10.1016/s0014-5793(99)00983-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TOP mRNAs are translationally inhibited by a titratable repressor in both wheat germ extract and reticulocyte lysate.PMID 10462043Read ↗

The 5' terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner.Semantic proximity Read ↗

La protein has a positive effect on the translation of TOP mRNAs in vivoSemantic proximity Read ↗

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.Semantic proximity Read ↗

Differential translation of TOP mRNAs in rapamycin-treated human B lymphocytes.Semantic proximity Read ↗

Infrequent translation of a nonsense codon is sufficient to decrease mRNA level.Semantic proximity Read ↗

Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6kSemantic proximity Read ↗

Antisense masking reveals contributions of mRNA-rRNA base pairing to translation of Gtx and FGF2 mRNAs.Semantic proximity Read ↗

The 5'-untranslated region of GM-CSF mRNA suppresses translational repression mediated by the 3' adenosine-uridine-rich element and the poly(A) tail.Semantic proximity Read ↗

Translational repression precedes and is required for ZAP‐mediated mRNA decaySemantic proximity Read ↗

Effect of 3'UTR length on the translational regulation of 5'-terminal oligopyrimidine mRNAs.Semantic proximity Read ↗

Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs.Semantic proximity Read ↗

Quantification analysis of translation initiation signal in vertebrate mRNAs: effect of nucleotides at positions +4(-)+6 upon efficiency of translation initiation.Semantic proximity Read ↗

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