Article
VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS).
Journal of neurogenetics - 1 Jan 2000
Terry Paul D, Kamel Freya, Umbach David M, Lehman Teresa A, Hu Howard, Sandler Dale P, Taylor Jack A
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a cytokine essential for angiogenesis. A recent study found that haplotypes, determined by three SNPs (-2,578C/A, - 1,154 G/A, and - 634G/C) in the VEGF upstream promoter/leader sequence, were associated with risk of amyotrophic lateral sclerosis(ALS). We used samples and data from a case-control study to examine the relation of ALS to VEGF haplotype. Genotypes at each...
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