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Article

Angiogenin protects motoneurons against hypoxic injury.

Cell death and differentiation - 1 Sept 2009

Sebastià J, Kieran D, Breen B, King M A, Netteland D F, Joyce D, Fitzpatrick S F, Taylor C T, Prehn J H M

Abstract excerpt

Cells can adapt to hypoxia through the activation of hypoxia-inducible factor-1 (HIF-1), which in turn regulates the expression of hypoxia-responsive genes. Defects in hypoxic signaling have been suggested to underlie the degeneration of motoneurons in amyotrophic lateral sclerosis (ALS). We have recently identified mutations in the hypoxia-responsive gene, angiogenin (ANG), in ALS patients, and have shown that...

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Source

Identifiers

PMID: 19444281
DOI: 10.1038/cdd.2009.52

Genes

ANG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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