Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Slc11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2003

Smit Joost J, Van Loveren Henk, Hoekstra Maarten O, Karimi Khalil, Folkerts Gert, Nijkamp Frans P

Abstract excerpt

Genes controlling antibacterial resistance may be important in the hygiene hypothesis, which states that lack of bacterial infections during childhood would favor development of allergic disease. We, therefore, studied whether Nramp1 (Slc11a1) alleles, which determine susceptibility (Nramp1(s)) or resistance (Nramp1(r)) to intracellular bacteria, affect the efficacy of heat-killed Mycobacterium vaccae in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allergens
Share to Bacterial Vaccines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Cellular

Share to Macrophage Activation

Share to Mice, Congenic

Share to Mice, Inbred DBA

Share to Mycobacterium

Share to T-Lymphocyte Subsets

Source

Identifiers

PMID: 12847242
DOI: 10.4049/jimmunol.171.2.754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Slc11a1 (Nramp1) gene controls efficacy of mycobacterial treatment of allergic asthma.PMID 12847242Read ↗

Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility.Semantic proximity Read ↗

The Nramp1 protein and its role in resistance to infection and macrophage function.Semantic proximity Read ↗

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.Semantic proximity Read ↗

Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.Semantic proximity Read ↗

NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population.Semantic proximity Read ↗

Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).Semantic proximity Read ↗

Clearance of infection with Mycobacterium bovis BCG in mice is enhanced by treatment with S28463 (R-848), and its efficiency depends on expression of wild-type Nramp1 (resistance allele).Semantic proximity Read ↗

Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice.Semantic proximity Read ↗

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story.Semantic proximity Read ↗

The Bcg host-resistance gene.Semantic proximity Read ↗

Reduced in vitro functional activity of human NRAMP1 (SLC11A1) allele that predisposes to increased risk of pediatric tuberculosis disease.Semantic proximity Read ↗

Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.