Article
Clearance of infection with Mycobacterium bovis BCG in mice is enhanced by treatment with S28463 (R-848), and its efficiency depends on expression of wild-type Nramp1 (resistance allele).
Antimicrobial agents and chemotherapy - 1 Nov 2001
Moisan J, Wojciechowski W, Guilbault C, Lachance C, Di Marco S, Skamene E, Matlashewski G, Radzioch D
Abstract excerpt
The mouse bcg host resistance gene is known to control the activation of host macrophages for killing of intracellular parasites like Leishmania donovani as well as intracellular bacteria, including Mycobacterium bovis BCG and Salmonella enterica serovar Typhimurium. The Nramp1 gene has been mapp...
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