Article
Large-scale generation of mature monocyte-derived dendritic cells for clinical application in cell factories.
Journal of immunological methods - 15 Oct 2002
Berger Thomas G, Feuerstein Bernadette, Strasser Erwin, Hirsch Ute, Schreiner Doris, Schuler Gerold, Schuler-Thurner Beatrice
Abstract excerpt
Dendritic cells (DC) are increasingly used for the immunotherapy of cancer. Both the induction of tumor-specific T cells and some clinical regressions have been observed in early phase I/II trials by using either DC isolated from blood, DC generated from CD34+ precursors ex vivo, and most frequently, by employing monocyte-derived DC. As DC vaccination is now awaiting phase II/III trials with larger patient...
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