Article
In vitro selection of viral vectors with modified tropism: the adeno-associated virus display.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jul 2003
Perabo Luca, Büning Hildegard, Kofler David M, Ried Martin U, Girod Anne, Wendtner Clemens M, Enssle Jörg, Hallek Michael
Abstract excerpt
Improving the efficiency and specificity of gene vectors is critical for the success of gene therapy. In an effort to generate viral mutants with controlled tropism we produced a library of adeno-associated virus (AAV) clones with randomly modified capsids and used it for the selection of receptor-targeting mutants. After several rounds of selection on different cell lines that were resistant to infection by...
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