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Article

Combinatorial engineering of a gene therapy vector: directed evolution of adeno-associated virus.

The journal of gene medicine - 1 Feb 2006

Perabo Luca, Endell Jan, King Susan, Lux Kerstin, Goldnau Daniela, Hallek Michael, Büning Hildegard

Abstract excerpt

BACKGROUND: Viruses are being exploited as vectors to deliver therapeutic genetic information into target cells. The success of this approach will depend on the ability to overcome current limitations, especially in terms of safety and efficiency, through molecular engineering of the viral particles. METHODS: Here we show that in vitro directed evolution can be successfully performed to randomize the viral capsid...

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Identifiers

PMID: 16285001
DOI: 10.1002/jgm.849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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