Article
Altering AAV tropism with mosaic viral capsids.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2005
Gigout Laure, Rebollo Patricia, Clement Nathalie, Warrington Kenneth H, Muzyczka Nicholas, Linden R Michael, Weber Thomas
Abstract excerpt
Over the past decade, AAV-based vectors have emerged as promising candidates for gene therapeutic applications. Despite the broad tropism of the first eight serotypes identified, certain cell types are refractory to transduction with AAV-based vectors. Furthermore, for certain applications the targeting of specific cell types is desirable. To improve on present methods to alter AAV2 tropism, we take advantage of...
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