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A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection

21 Feb 2009

Abstract excerpt

To engineer gene vectors that target striated muscles after systemic delivery, we constructed a random library of adeno-associated virus (AAV) by shuffling the capsid genes of AAV serotypes 1 to 9, and screened for muscle-targeting capsids by direct in vivo panning after tail vein injection in mice. After 2 rounds of in vivo selection, a capsid gene named M41 was retrieved mainly based on its high frequency in...

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PMID: 19234115
DOI: 10.1073/pnas.0813207106

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