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Article

Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.

Psychiatric genetics - 1 Sept 2000

Nolan K A, Volavka J, Czobor P, Cseh A, Lachman H, Saito T, Tiihonen J, Putkonen A, Hallikainen T, Kotilainen I, Räsänen P, Isohanni M, Järvelin M R, Karvonen M K

Abstract excerpt

A common functional polymorphism that results in a three- to four-fold difference in catechol-O-methyltransferase (COMT) enzyme activity has been related to psychiatric disorders such as ultra-ultra rapid cycling bipolar disorder, drug abuse and alcoholism (Lachman et al., 1996a; Karayiorgou et a...

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Source

Identifiers

PMID: 11204347
DOI: 10.1097/00041444-200010030-00003

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11204347-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Suicidal behavior in patients with schizophrenia is related to COMT polymorphism.PMID 11204347Read ↗

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Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.Semantic proximity Read ↗

Aggressive behavior in schizophrenia is associated with the low enzyme activity COMT polymorphism: a replication study.Semantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

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Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior.Semantic proximity Read ↗

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