Article
No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders.
Archives of suicide research : official journal of the International Academy for Suicide Research - 1 Jan 2008
Zalsman Gil, Huang Yung-yu, Oquendo Maria A, Brent David A, Giner Lucas, Haghighi Fatemeh, Burke Ainsley K, Ellis Steven P, Currier Dianne, Mann J John
Abstract excerpt
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) is associated with lower enzymatic activity than the Val allele and is reported to be associated with aggression, depression, and suicidal behavior. Since depression and impulsive-aggressive behavior may mediate risk for suicidal behavior, we assessed the association of this polymorphism with suicidal behavior....
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