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Article

Val158Met COMT polymorphism and risk of aggression in alcohol dependence.

Addiction biology - 1 Jan 2015

Soyka Michael, Zill Peter, Koller Gabi, Samochowiec Agnieszka, Grzywacz Anna, Preuss Ulrich W

Abstract excerpt

Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24118473
DOI: 10.1111/adb.12098

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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