Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.

The Journal of clinical investigation - 15 Oct 1998

Liggett S B, Wagoner L E, Craft L L, Hornung R W, Hoit B D, McIntosh T C, Walsh R A

Abstract excerpt

The beta2-adrenergic receptor (beta2AR), an important modulator of cardiac inotropy and chronotropy, has significant genetic heterogeneity in the population. Because dysfunctional betaARs play a role in the pathogenesis of the failing ventricle, we tested the hypothesis that beta2AR polymorphisms...

Topics

Join the communities discussing this publication.

Alleles
Genotype
Polymorphism, Genetic
Gene Frequency
Models, Biological
Treatment Outcome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 9788966
DOI: 10.1172/JCI4059
PMCID: PMC509003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9788966-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.PMID 9788966Read ↗

Ile164 variant of beta2-adrenoceptor does not influence outcome in heart failure but may interact with beta blocker treatment.Semantic proximity Read ↗

Impact of beta-2 Thr164Ile and combined beta-adrenergic receptor polymorphisms on prognosis in a cohort of heart failure outpatients.Semantic proximity Read ↗

Is there a role of the Thr164Ile-beta(2)-adrenoceptor polymorphism for the outcome of chronic heart failure?Semantic proximity Read ↗

Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure.Semantic proximity Read ↗

Blunted cardiac responses to receptor activation in subjects with Thr164Ile beta(2)-adrenoceptors.Semantic proximity Read ↗

Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy.Semantic proximity Read ↗

Polymorphisms of the beta(2)-adrenergic receptor determine exercise capacity in patients with heart failure.Semantic proximity Read ↗

The Arg16Gly-β(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure.Semantic proximity Read ↗

Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.Semantic proximity Read ↗

Beta1- and beta2-adrenoceptor polymorphisms and cardiovascular diseases.Semantic proximity Read ↗

Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure.Semantic proximity Read ↗

Beta2-adrenoceptor gene polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.