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Article

Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest.

Molecular and cellular biology - 1 Jul 2003

Yaakov Gilad, Bell Michal, Hohmann Stefan, Engelberg David

Abstract excerpt

Mitogen-activated protein kinases (MAPKs) play key roles in differentiation, growth, proliferation, and apoptosis. Although MAPKs have been extensively studied, the precise function, specific substrates, and target genes of each MAPK are not known. These issues could be addressed by sole activation of a given MAPK, e.g., through the use of constitutively active MAPK enzymes. We have recently reported the...

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Identifiers

PMID: 12832470
DOI: 10.1128/MCB.23.14.4826-4840.2003
PMCID: PMC162220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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