Article
Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α.
PloS one - 1 Jan 2012
Maayan Inbal, Beenstock Jonah, Marbach Irit, Tabachnick Shira, Livnah Oded, Engelberg David
Abstract excerpt
Many protein kinases require phosphorylation at their activation loop for induction of catalysis. Mitogen-activated protein kinases (MAPKs) are activated by a unique mode of phosphorylation, on neighboring Tyrosine and Threonine residues. Whereas many kinases obtain their activation via autophosp...
Topics
- Fungal Proteins
- Gene Expression Regulation, Enzymologic
- HEK293 Cells
- Humans
- MAP Kinase Kinase 6
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinase 14
- Mitogen-Activated Protein Kinases
- Models, Genetic
- Mutation
- Osmotic Pressure
- Phosphorylation
- Plasmids
- Protein Structure, Tertiary
- Saccharomyces cerevisiae Proteins