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Article

Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.

Molecular biology of the cell - 1 Sept 2016

Goshen-Lago Tal, Goldberg-Carp Anat, Melamed Dganit, Darlyuk-Saadon Ilona, Bai Chen, Ahn Natalie G, Admon Arie, Engelberg David

Abstract excerpt

MAP kinases of the ERK family are conserved from yeast to humans. Their catalytic activity is dependent on dual phosphorylation of their activation loop's TEY motif, catalyzed by MAPK kinases (MEKs). Here we studied variants of Mpk1, a yeast orthologue of Erk, which is essential for cell wall integrity. Cells lacking MPK1, or the genes encoding the relevant MEKs, MKK1 and MKK2, do not proliferate under cell wall...

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Identifiers

PMID: 27413009
DOI: 10.1091/mbc.E16-03-0167
PMCID: PMC5007096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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