Article
Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.
The Journal of biological chemistry - 12 Dec 2008
Levin-Salomon Vered, Kogan Konstantin, Ahn Natalie G, Livnah Oded, Engelberg David
Abstract excerpt
MAPKs are key components of cell signaling pathways with a unique activation mechanism: i.e. dual phosphorylation of neighboring threonine and tyrosine residues. The ERK enzymes form a subfamily of MAPKs involved in proliferation, differentiation, development, learning, and memory. The exact role of each Erk molecule in these processes is not clear. An efficient strategy for addressing this question is to...
Topics
- Amino Acid Sequence
- Animals
- Extracellular Signal-Regulated MAP Kinases
- Gene Expression Regulation, Enzymologic
- Genetic Complementation Test
- Humans
- MAP Kinase Signaling System
- Mice
- Molecular Sequence Data
- Mutation
- NIH 3T3 Cells
- Phosphorylation
- Recombinant Proteins