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Article

Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

The Journal of biological chemistry - 12 Dec 2008

Levin-Salomon Vered, Kogan Konstantin, Ahn Natalie G, Livnah Oded, Engelberg David

Abstract excerpt

MAPKs are key components of cell signaling pathways with a unique activation mechanism: i.e. dual phosphorylation of neighboring threonine and tyrosine residues. The ERK enzymes form a subfamily of MAPKs involved in proliferation, differentiation, development, learning, and memory. The exact role of each Erk molecule in these processes is not clear. An efficient strategy for addressing this question is to...

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Identifiers

PMID: 18829462
DOI: 10.1074/jbc.M806443200
PMCID: PMC3259889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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