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Article

Novel PKCeta is required to activate replicative functions of the major nonstructural protein NS1 of minute virus of mice.

Journal of virology - 1 Jul 2003

Lachmann Sylvie, Rommeleare Jean, Nüesch Jürg P F

Abstract excerpt

The multifunctional protein NS1 of minute virus of mice (MVMp) is posttranslationally modified and at least in part regulated by phosphorylation. The atypical lambda isoform of protein kinase C (PKClambda) phosphorylates residues T435 and S473 in vitro and in vivo, leading directly to an activation of NS1 helicase function, but it is insufficient to activate NS1 for rolling circle replication. The present study...

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Share to Cell Nucleus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

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Source

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Identifiers

PMID: 12829844
DOI: 10.1128/jvi.77.14.8048-8060.2003
PMCID: PMC161934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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