Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic Replication

29 Jul 2010

Abstract excerpt

Upon viral infection, the mitochondrial antiviral signaling (MAVS)-IKKbeta pathway is activated to restrict viral replication. Manipulation of immune signaling events by pathogens has been an outstanding theme of host-pathogen interaction. Here we report that the loss of MAVS or IKKbeta impaired the lytic replication of gamma-herpesvirus 68 (gammaHV68), a model herpesvirus for human Kaposi's sarcoma-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to interferon and immune responses
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20686657
DOI: 10.1371/journal.ppat.1001001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKKβ to Initiate Lytic ReplicationPMID 20686657Read ↗

Infection-Induced Retrotransposon-Derived Noncoding RNAs Enhance Herpesviral Gene Expression via the NF-κB PathwaySemantic proximity Read ↗

A Gammaherpesvirus Cooperates with Interferon-alpha/beta-Induced IRF2 to Halt Viral Replication, Control Reactivation, and Minimize Host LethalitySemantic proximity Read ↗

Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.Semantic proximity Read ↗

Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68Semantic proximity Read ↗

Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary InfectionSemantic proximity Read ↗

Unraveling the Kaposi Sarcoma-Associated Herpesvirus (KSHV) Lifecycle: An Overview of Latency, Lytic Replication, and KSHV-Associated DiseasesSemantic proximity Read ↗

RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription ActivatorSemantic proximity Read ↗

A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology.Semantic proximity Read ↗

Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication.Semantic proximity Read ↗

Rta of Murine Gammaherpesvirus 68 Reactivates the Complete Lytic Cycle from LatencySemantic proximity Read ↗

A Viral-Encoded Homologue of IPS-1 Modulates Innate Immune Signaling During KSHV Lytic ReplicationSemantic proximity Read ↗

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic ReplicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.