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Article

Hippocampal expression of a virus-derived protein impairs memory in mice.

Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2018

Bétourné Alexandre, Szelechowski Marion, Thouard Anne, Abrial Erika, Jean Arnaud, Zaidi Falek, Foret Charlotte, Bonnaud Emilie M, Charlier Caroline M, Suberbielle Elsa, Malnou Cécile E, Granon Sylvie, Rampon Claire, Gonzalez-Dunia Daniel

Abstract excerpt

The analysis of the biology of neurotropic viruses, notably of their interference with cellular signaling, provides a useful tool to get further insight into the role of specific pathways in the control of behavioral functions. Here, we exploited the natural property of a viral protein identified as a major effector of behavioral disorders during infection. We used the phosphoprotein (P) of Borna disease virus,...

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Identifiers

PMID: 29378968
DOI: 10.1073/pnas.1711977115
PMCID: PMC5816149

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