Article
Evidence that GPVI is Expressed as a Mixture of Monomers and Dimers, and that the D2 Domain is not Essential for GPVI Activation.
Thrombosis and haemostasis - 1 Nov 2021
Clark Joanne C, Neagoe Raluca A I, Zuidscherwoude Malou, Kavanagh Deirdre M, Slater Alexandre, Martin Eleyna M, Soave Mark, Stegner David, Nieswandt Bernhard, Poulter Natalie S, Hummert Johan, Herten Dirk-Peter, Tomlinson Michael G, Hill Stephen J, Watson Steve P
Abstract excerpt
Collagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI) and the number of GPVI dimers has been reported to increase upon platelet activation. However, in contrast, the crystal structure of GPVI in complex with collagen-related peptide (CRP) showed binding distinct from the site of dimerization. Further fibrinogen has been reported to bind to monomeric but not dimeric GPVI. In the...
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