Article
Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis.
Molecular biology of the cell - 1 Apr 2002
Walker Denise S, Gower Nicholas J D, Ly Sung, Bradley Gemma L, Baylis Howard A
Abstract excerpt
Inositol 1,4,5-trisphosphate (IP(3)) is an important second messenger in animal cells and is central to a wide range of cellular responses. The major intracellular activity of IP(3) is to regulate release of Ca(2+) from intracellular stores through IP(3) receptors (IP(3)Rs). We describe a system for the transient disruption of IP(3) signaling in the model organism Caenorhabditis elegans. The IP(3) binding domain...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Cell Division
- DNA, Complementary
- Dose-Response Relationship, Drug
- Gastrula
- Genes, Dominant
- Hot Temperature
- Inositol 1,4,5-Trisphosphate