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Article

Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2003

Alsene Karen, Deckert Jürgen, Sand Philipp, de Wit Harriet

Abstract excerpt

The adenosine receptor system, which mediates the psychoactive effects of caffeine, is also thought to be involved in the regulation of anxiety. In this study, we examined the association between variations in anxiogenic responses to caffeine and polymorphisms in the A1 and A2a adenosine receptor genes. Healthy, infrequent caffeine users (N=94) recorded their subjective mood states following a 150 mg oral dose of...

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Identifiers

PMID: 12825092
DOI: 10.1038/sj.npp.1300232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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