Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.

doi:10.1038/npp.2010.71

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Article

Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2010

Rogers Peter J, Hohoff Christa, Heatherley Susan V, Mullings Emma L, Maxfield Peter J, Evershed Richard P, Deckert Jürgen, Nutt David J

Abstract excerpt

Caffeine, a widely consumed adenosine A(1) and A(2A) receptor antagonist, is valued as a psychostimulant, but it is also anxiogenic. An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported for individuals who habitually consume little caffeine. This study investigated whether this single nucleotide polymorphism (SNP) might also affect habitual caffeine...

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PMID: 20520601
DOI: 10.1038/npp.2010.71
PMCID: PMC3055635

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ADORA1

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