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Article

Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2008

Childs Emma, Hohoff Christa, Deckert Jürgen, Xu Ke, Badner Judith, de Wit Harriet

Abstract excerpt

Caffeine produces mild psychostimulant and sometimes anxiogenic effects by antagonizing adenosine at A(1) and A(2A) receptors, and perhaps through interactions with other transmitter systems. Adenosine receptors are colocalized and functionally interact with dopamine receptors in the brain. Thus, functional polymorphisms in the genes for either adenosine or dopamine receptors may affect responses to caffeine. In...

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Source

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Identifiers

PMID: 18305461
DOI: 10.1038/npp.2008.17
PMCID: PMC2745641

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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