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Article

Caffeine consumption and behavioral symptoms: influence of ADORA2A and DRD2 genes on inattention.

European journal of nutrition - 1 Nov 2025

Genro Júlia Pasqualini, Dresch Fabiane, Wünsch Camile, Fraporti Thailan Teles, Tovo-Rodrigues Luciana, Contini Verônica

Abstract excerpt

BACKGROUND: Caffeine acts on the central nervous system by antagonizing adenosine receptors, promoting alertness as adenosine regulates sleep and wakefulness. It has also an indirect stimulating effect by increasing dopamine neurotransmission, mediated by A2A (ADORA2A) and D2 (DRD2) receptors, which are co-localized in dopamine-rich brain regions. PURPOSE: This study investigates the association between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Adenosine A2A

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Source

Identifiers

PMID: 41175253
DOI: 10.1007/s00394-025-03832-5

Genes

ADORA2A
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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