Article
Interindividual variation in anxiety response to amphetamine: possible role for adenosine A2A receptor gene variants.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Nov 2005
Hohoff Christa, McDonald Jennifer M, Baune Bernhard T, Cook Edwin H, Deckert Jürgen, de Wit Harriet
Abstract excerpt
Amphetamine is thought to produce its stimulant effects mainly via the dopamine system, but its effects may also be influenced by other systems. Dopamine D1 and D2 receptors exist as heterodimers with adenosine A1 and A(2A) receptors, which modulate their responsiveness, suggesting that responses to amphetamine may also depend on adenosinergic function. We therefore studied the relevance of one adenosine A1 and...
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