Article
Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 1994
Vandevyver C, Raus P, Stinissen P, Philippaerts L, Cassiman J J, Raus J
Abstract excerpt
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF-beta*2 allele was observed in HLA-DR2+ vs. HLA-DR2- MS patients. No such association was seen in HLA-DR4+ RA...
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