A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis.

doi:10.1212/wnl.49.2.626

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Article

A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis.

Neurology - 1 Aug 1997

Wingerchuk D, Liu Q, Sobell J, Sommer S, Weinshenker B G

Abstract excerpt

Tumor necrosis factor alpha (TNF alpha) expression is enhanced in patients with active MS and other inflammatory diseases. A guanine-to-adenine polymorphism at position -308 of the TNF alpha promoter region (the TNF2 allele) is associated with increased TNF alpha expression. We evaluated 110 MS p...

Topics

Alleles
Autoimmune Diseases
Case-Control Studies
Cohort Studies
Gene Frequency
Humans
Infections
Multiple Sclerosis
Nervous System Diseases
Polymorphism, Genetic
Tumor Necrosis Factor-alpha

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