Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis.

doi:10.1016/0165-5728(95)00138-7

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Article

Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis.

Journal of neuroimmunology - 31 Dec 1995

He B, Navikas V, Lundahl J, Söderström M, Hillert J

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, is believed to play an important role in multiple sclerosis (MS) pathogenesis. A bi-allelic polymorphism in the TNF-alpha promoter region (TNF alpha-308), has been reported to influence levels of TNF-alpha production. In the pre...

Topics

Alleles
Base Sequence
Gene Expression
Genetic Linkage
Genotype
HLA-D Antigens
Haplotypes
Humans
Molecular Sequence Data
Multiple Sclerosis
Optic Neuritis
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic
RNA, Messenger
Tumor Necrosis Factor-alpha

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Open in PubMed

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PMID: 8550811
DOI: 10.1016/0165-5728(95)00138-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8550811-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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