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Article

Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis.

Journal of neuroimmunology - 31 Dec 1995

He B, Navikas V, Lundahl J, Söderström M, Hillert J

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, is believed to play an important role in multiple sclerosis (MS) pathogenesis. A bi-allelic polymorphism in the TNF-alpha promoter region (TNF alpha-308), has been reported to influence levels of TNF-alpha production. In the present study, we investigated the TNF alpha-308 polymorphism in 93 patients with MS, 17 patients with optic neuritis (ON)...

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Identifiers

PMID: 8550811
DOI: 10.1016/0165-5728(95)00138-7

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis.PMID 8550811Read ↗

Decreased frequency of the tumor necrosis factor alpha -308 allele in Serbian patients with multiple sclerosis.Semantic proximity Read ↗

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A population-based case-control study of the tumor necrosis factor alpha-308 polymorphism in multiple sclerosis.Semantic proximity Read ↗

TNF-alpha polymorphisms in multiple sclerosis: no association with -238 and -308 promoter alleles, but the microsatellite allele a11 is associated with the disease in French patients.Semantic proximity Read ↗

Gene polymorphism at position -308 of the tumor necrosis factor alpha promotor is not associated with disease progression in multiple sclerosis patients.Semantic proximity Read ↗

TNF-alpha promoter polymorphisms in multiple sclerosis: no association with -308 and -238 alleles, but the -857 alleles in associated with the disease in Turkish patients.Semantic proximity Read ↗

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