Induction of Adhesion-Inhibitory Antibodies against Placental<i>Plasmodium falciparum</i>Parasites by Using Single Domains of VAR2CSA

Abstract excerpt

In areas of endemicity pregnancy-associated malaria is an important cause of maternal anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by the accumulation of Plasmodium falciparum-infected erythrocytes in the placenta, mediated through an interaction between a parasite protein expressed on erythrocytes named variant surface antigen 2-chondroitin sulfate A (VAR2CSA) and...