Article
The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society - 1 Jun 2003
Sykiotis Gerasimos P, Polyzogopoulou Eftihia, Georgopoulos Neoklis A, Trakada Georgia, Spyropoulos Kostas, Kalfarentzos Fotios, Papavassiliou Athanasios G, Vagenakis Apostolos G, Flordellis Christodoulos S
Abstract excerpt
The sympathetic nervous system participates in the regulation of the basal metabolic rate (BMR) and in the manifestation of the obesity-related metabolic syndrome. A deletion/insertion germline polymorphism of the alpha(2B) adrenergic receptor that is associated with reduced agonist-promoted desensitization has been linked to low BMR in obese subjects and to a predisposition to gain weight. This study...
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