Article
The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.
The Journal of clinical endocrinology and metabolism - 1 Aug 1998
Büettner R, Schäffler A, Arndt H, Rogler G, Nusser J, Zietz B, Enger I, Hügl S, Cuk A, Schölmerich J, Palitzsch K D
Abstract excerpt
The beta3-adrenergic receptor (3-BAR) is assumed to play a role in the regulation of energy balance by increasing lipolysis and thermogenesis. A recently detected allelic polymorphism (Trp64Arg polymorphism) has been suggested to contribute to the development of obesity and non-insulin-dependent...
Topics
- Adult
- Aging
- Alleles
- Arginine
- Body Mass Index
- Body Temperature Regulation
- Body Weight
- Cholesterol
- Cohort Studies
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Energy Metabolism
- Female
- Genotype