Article
Polymorphism of the beta 3-adrenergic receptor gene in morbid obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Dec 1996
Oksanen L, Mustajoki P, Kaprio J, Kainulainen K, Jänne O, Peltonen L, Kontula K
Abstract excerpt
OBJECTIVE: The Trp64-->Arg allele of the beta 3-adrenergic receptor gene was recently proposed to be associated with an earlier onset of non-insulin-dependent diabetes mellitus (NIDDM), features of insulin resistance and a tendency to gain weight. We investigated whether the Arg64 allele predisposes to severe obesity. DESIGN AND SUBJECTS: A genetic association study of 254 subjects with morbid obesity [body-mass...
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